Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). Curcumin is an active ingredient in the traditional herbal remedy and dietary spice turmeric (Curcuma longa). It is used as an ancient Medicine. Curcumin has a surprisingly wide range of beneficial properties, including antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities. Curcumin, these effects are mediated through the regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases, and other enzymes. Various clinical trials have shown that Curcumin exhibit very poor bio-availability. Major reasons contributing to the low plasma and tissue levels of Curcumin appear to be due to poor water solubility, poor absorption, rapid metabolism, and rapid systemic elimination.
Despite the lower bio-availability, therapeutic efficacy of curcumin against various human diseases, including cancer, Alzheimer’s disease, cardiovascular diseases, diabetes, arthritis, neurological diseases and Crohn’s disease, has been documented. Enhanced water solubility, thus by bio-availability of curcumin in the near future is likely (we had it already, CURCLEAR) to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease.
Curcumin is strongly anti-inflammatory; it is so powerful that it matches the effectiveness of some anti-inflammatory drugs. Curcumin actually targets multiple steps in the inflammatory pathway, at the molecular level. Curcumin blocks NF-kB, a molecule that travels into the nuclei of cells and turns on genes related to inflammation. NF-kB is believed to play a major role in many chronic diseases. So Curcumin can effectively target it.
Oxidative damage is believed to be one of the mechanisms behind ageing and many diseases. It involves free radicals, highly reactive molecules with unpaired electrons.Free radicals tend to react with important organic substances, such as fatty acids, proteins or DNA.
The main reason antioxidants are so beneficial, is that they protect our bodies from free radicals. Curcumin happens to be a potent antioxidant that can neutralize free radicals due to its chemical structure. Curcumin also boosts the activity of the body’s own antioxidant enzymes. In that way, curcumin delivers a one-two punch against free radicals. It blocks them directly, then stimulates the body’s own antioxidant mechanisms.